• Glucose and Insulin Levels 
  • Second-Meal Effect
  • Metabolic Health Implications

In 2012, a group of scientists led by Dr. Daniel König tested Almased in a group of 11 overweight or obese men with metabolic syndrome and insulin resistance.

In this trial, which was called “The Breakfast Study,” after an overnight fast participants received either Almased as a meal replacement or a standard breakfast. Four hours after the start of the intervention, all subjects ate a standard lunch. 

Glucose and Insulin Levels 

In the first two hours after breakfast, glucose levels were significantly lower for the meal-replacement.  

In addition, area under the curve (AUC) glucose was markedly lower in the first four hours after breakfast for the supplemented participants. 

After lunch, insulin concentrations were decreased in the supplemented participants compared to the non-supplemented subjects; AUC insulin was also significantly lower. 

One fascinating finding in this study was the significantly increased fat oxidation in the supplemented group versus those who just had the standard breakfast.

Happy full man touching tummy smiling in kitchen                                                                                                  

The Second-Meal Effect                       

In addition, the levels of the hunger hormone, ghrelin, were significantly decreased in the two hours after breakfast in the supplemented group. 

König and his team noted these benefits even up to several hours after breakfast, in fact until after lunch, a benefit known as the “second meal effect.” 

The authors believe that the significantly greater decrease in ghrelin levels, along with a trend towards higher peptide-YY concentrations, in the post-meal period likely contributed to the greater and longer satiety found after the Almased meal replacement. 

Potential Benefits for Your Patients 

It is known that fat burning is decreased in people who are obese, especially in those with metabolic syndrome, and it is believed to lead to intracellular fat accumulationlipo-toxicity and insulin resistance 

The authors write that the increase in fat oxidation after the meal replacement “could account not only for better weight loss but also for the observed rapid improvement in metabolic risk factors,” which has exciting implications for diabetes risk.


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